levkemija (104 od skupno 1332 raziskav)
"The average annual age-standardised incidence was 137·5 (95% CI 136·7-138·3) per million person-years and incidence increased significantly by 0·54% (0·44-0·65) per year in children (age 0-14 years) with no change in trend. In adolescents, the combined European incidence was 176·2 (174·4-178·0) per million person-years based on all 35 138 eligible cases and increased significantly by 0·96% (0·73-1·19) per year, although recent changes in rates among adolescents suggest a deceleration in this increasing trend. We observed temporal variations in trends by age group, geographical region, and diagnostic group. The combined age-standardised incidence of leukaemia based on 48 458 cases in children was 46·9 (46·5-47·3) per million person-years and increased significantly by 0·66% (0·48-0·84) per year. The average overall incidence of leukaemia in adolescents was 23·6 (22·9-24·3) per million person-years, based on 4702 cases, and the average annual change was 0·93% (0·49-1·37). We also observed increasing incidence of lymphoma in adolescents (average annual change 1·04% [0·65-1·44], malignant CNS tumours in children (average annual change 0·49% [0·20-0·77]), and other tumours in both children (average annual change 0·56 [0·40-0·72]) and adolescents (average annual change 1·17 [0·82-1·53])."
"In this review, we discuss the possibility that carcinogenic effects are based on the radical pair mechanism (RPM), which seems to be involved in magnetoreception in birds and certain other animals, allowing navigation in the geomagnetic field. We review the current understanding of the RPM in magnetoreception, and discuss cryptochromes as the putative magnetosensitive molecules and their possible links to cancer-relevant biological processes. We then propose a hypothesis for explaining the link between ELF fields and childhood leukaemia, discuss the strengths and weaknesses of the current evidence, and make proposals for further research."
"The consistent association of RFR and highly elevated HL cancer risk in the four groups spread over three countries, operating different RFR equipment types and analyzed by different research protocols, suggests a cause-effect relationship between RFR and HL cancers in military/occupational settings. While complete measurements of RFR exposures were not available and rough exposure assessments from patients interviews and from partial exposure data were used instead, we have demonstrated increased HL cancers in occupational groups with relatively high RFR exposures. Our findings, combined with other studies, indicate that exposures incurred in the military settings evaluated here significantly increased the risk of HL cancers. Accordingly, the RFR military exposures in these occupations should be substantially reduced and further efforts should be undertaken to monitor and measure those exposures and to follow cohorts exposed to RFR for cancers and other health effects. Overall, the epidemiological studies on excess risk for HL and other cancers together with brain tumors in cellphone users and experimental studies on RFR and carcinogenicity make a coherent case for a cause-effect relationship and classifying RFR exposure as a human carcinogen (IARC group 1)."
"We studied groups of male and female Sprague-Dawley rats exposed from prenatal life until natural death to 20 or 1000 μT S-50 Hz MF and also to 0.1 Gy γ radiation delivered as a single acute exposure at 6 weeks of age. The results of the study showed significant carcinogenic effects for the mammary gland in males and females and a significant increased incidence of malignant schwannomas of the heart as well as increased incidence of lymphomas/leukemias in males. These results call for a re-evaluation of the safety of non-ionizing radiation."
"These data support the hypothesis that long-term exposure of 50 Hz magnetic fields is a significant risk factor for neoplastic development and fertility in mice."
"The results show that the main contribution in terms of induced electric fields to the foetal exposure is given by the fundamental frequency component. The harmonic components add some contributions to the overall level of electric fields, however, due to the extremely low permitted amplitude of the harmonic components with respect to the fundamental, their amplitudes are low."
"These new insights might be important in establishing a mechanistic framework at the molecular level within which the possible effects of ELF-EMF on health can be understood."
"Present manuscript reviews evidences of altered brain physiology and stem cell functioning due to mobile phone/cell tower radiations, its association with increased cancer risk and explores early diagnostic value of EPI imaging in detecting EMF induced changes on human BEM."
"Since, varying the parameters of EMFs different effects may be observed, we have studied MCP-1 expression in HaCaT, SH-SY5Y, THP-1 and K562 exposed to a sinusoidal EMF at 50 Hz frequency with a flux density of 1 mT (rms). Our preliminary results showed that EMF-exposure differently modifies the expression of MCP-1 in different cell types. Thus, the MCP-1 expression needs to be better determined, with additional studies, with different parameters and times of exposure to ELF-EMF."
"Several studies with appropriate methodologies reflect the capacity of electromagnetic radiations to cause adverse health effects and there are several credible mechanisms that can account for the observed effects. Hence, need of the hour is to activate comprehensive well-coordinated blind scientific investigations, overcoming all limitations and demerits of previous investigations especially replication studies to concretize the earlier findings. Furthermore, appropriate exposure assessment is crucial for identification of dose-response relation if any, and the elucidation of biological interaction mechanism. For the time being, the public should follow the precautionary principle and limit their exposure as much as possible."
"This review concludes that the regular and long term use of microwave devices (mobile phone, microwave oven) at domestic level can have negative impact upon biological system especially on brain. It also suggests that increased reactive oxygen species (ROS) play an important role by enhancing the effect of microwave radiations which may cause neurodegenerative diseases."
"On the basis of two decades of epidemiological studies, an increased risk for childhood leukemia associated with Extremely Low Frequency fields has been consistently assessed, inducing the International Agency for Research on Cancer to insert them in the 2B section of carcinogens in 2001. EMFs interaction with biological systems may cause oxidative stress under certain circumstances. Since free radicals are essential for brain physiological processes and pathological degeneration, research focusing on the possible influence of the EMFs-driven oxidative stress is still in progress, especially in the light of recent studies suggesting that EMFs may contribute to the etiology of neurodegenerative disorders."
"2.45 GHz electromagnetic radiation appears to induce proliferative effects through oxidative stress and Ca²⁺ influx although blocking of transient receptor potential melastatin 2 channels by 2-aminoethyl diphenylborinate seems to counteract the effects on Ca²⁺ ions influx."
"The potential impact of EMF exposure on public health is probably limited, although in some countries exposure might be relatively high and thus might have a more substantial impact. We recommend nationwide surveys in order to gain more insight into the contemporary exposure levels among children. Reducing exposure from power lines near densely populated areas and schools is advised. Future epidemiological studies should focus on limiting bias."
"Collectively, these data indicate that 900 MHz MW-EMF acts as DNA damage signal at short time of exposure thus leading to an early activation of genes involved either in double- or single-strand DNA repair process as well as in the cell cycle arrest. Although this activation, the acute T-lymphoblastoid leukemia cells are unable to achieve growth arrest since the downstream effectors of both DNA repair and G1 phase genes are down-expressed either at early and late high-frequency EMF exposure times. Furthermore, in tumor cells the 900 MHz MW-EMF acts as negative regulator of genes involved in the control of chromosomal organization and in the inhibition of angiogenesis thus leading to tumor progression and metastatic transformation."
"The radical pair mechanism and related cryptochromes (CRY) molecules have recently been identified in birds and other non-mammalian species, as a sensor of the geomagnetic field, involved in navigation. The hypothesis has to be tested in mammalian models. CRY, which is part of the molecular circadian clock machinery, is a ubiquitous protein likely to be involved in cancer cell growth and DNA repair. In summary, we now have some clues to test for a better characterization of the interaction between ALL and ELF MFs exposure."
"Overall, the assessment that ELF-MF are a possible carcinogen and may cause childhood leukaemia remains valid. Ongoing research activities, mainly experimental and few new epidemiological studies, hopefully provide additional insight to bring clarity to a research area that has remained inconclusive."
"Through employing the alternate cut points, stratification by level of exposure or distance and the relation on different ways of exposure, there appeared consistent evidence of increased risk between acute myeloid leukemia in adults and the extremely low frequency-electromagnetic to field exposure."
"Children living within 200m of power lines presented an increased risk of ALL (OR 1.67; 95% CI 0.49-5.75), compared to children living at 600m or more of power lines. For those living within 50m of power lines the OR was 3.57 (95% CI 0.41-31.44)."
"Extremely low-frequency (ELF) MFs up to several tens of uT were measured in the mentioned working environments. 25% of the measured MFs were found less than 0.3 uT, the background exposure level that staff receive at home, 75% were above 0.3 uT with the highest value of 6.8 uT. The mean and median personal exposures were calculated to be 1.19 uT and 0.56 uT, respectively. Most of the staff (83%) is under risk based on epidemiological studies that reported a statistically significant association between risk of leukemia and averaged magnetic fields of 0.2 uT or over. Results showed that risk evaluation should be considered to minimize the possibility of the workers being harmed due to exposure to work-related electromagnetic sources."
"The debate shows how the EC risk management framework can be used to apply the Precautionary Principle to small and uncertain public health risks. However, despite the need for evidence-based policy making, many of the decisions remain value driven and therefore subjective."
"Our results are in line with previous pooled analyses showing an association between magnetic fields and childhood leukaemia. Overall, the association is weaker in the most recently conducted studies, but these studies are small and lack methodological improvements needed to resolve the apparent association. We conclude that recent studies on magnetic fields and childhood leukaemia do not alter the previous assessment that magnetic fields are possibly carcinogenic."
"Although not statistically significant, the estimate for childhood leukaemia resembles results of comparable studies. Assuming causality, the estimated attributable risk is below one case per year. Magnetic-field exposure during the year of birth is unlikely to be the whole cause of the association with distance from overhead power lines that we previously reported."
"Childhood exposure to physical contamination, including non-ionizing radiation, has been implicated in numerous diseases, raising concerns about the widespread and increasing sources of exposure to this type of radiation. The primary objective of this review was to analyze the current state of knowledge on the association between environmental exposure to non-ionizing radiation and the risk of childhood leukemia. Scientific publications between 1979 and 2008 that include examination of this association have been reviewed using the MEDLINE/PubMed database. Studies to date have not convincingly confirmed or ruled out an association between non-ionizing radiation and the risk of childhood leukemia. Discrepancies among the conclusions of the studies may also be influenced by confounding factors, selection bias, and misclassification. Childhood defects can result from genetic or epigenetic damage and from effects on the embryo or fetus, which may both be related to environmental exposure of the parent before conception or during the pregnancy. It is therefore critical for researchers to define a priori the type and "window" of exposure to be assessed. Methodological problems to be solved include the proper diagnostic classification of individuals and the estimated exposure to non-ionizing radiation, which may act through various mechanisms of action. There appears to be an urgent need to reconsider exposure limits for low frequency and static magnetic fields, based on combined experimental and epidemiological research into the relationship between exposure to non-ionizing radiation and adverse human health effects."
"We obtained five exposure data sets, applied several candidate dose-response relationships to each one, and performed a regression analysis to see how well they fit each of the three epidemiological data sets. Threshold dose-response relationships performed only moderately. Linear relationships were generally even poorer. The fit was improved by adding quadratic terms or performing non-linear regression. There are limitations in our analysis, stemming from the available data, but addressing this issue in a data-based, quantitative manner should improve understanding, allow better calculations to be made of attributable numbers, and hence ultimately inform public policy making."
"This ratio estimated as 9.93 (95%CI: 3.47 to 28.5) for 123 KV, 10.78 (95%CI: 3.75 to 31) for 230 KV and 2.98 (95%CI: 0.93 to 9.54) for 400 KV lines. Odds of ALL decreased 0.61 for every 600 meters from the nearest power line. This study emphasizes that living close to high voltage power lines is a risk for ALL."
"The IARC has classified EMF as a "possible carcinogen" which refers to the circumstances where there is limited evidence of carcinogenicity in humans and inadequate evidence in experimental animals. The IARC review indicated limited evidence for the carcinogenicity of extremely low-frequency magnetic fields in relation to childhood leukemia at high level exposure in the residential environment (average residential magnetic field strength greater than 0.4 uT). Even higher levels of exposure in the occupational environment may increase the risk of leukemia in adults."
"RESULTS: Relative risk of leukemia associated with antecedent residence in the area with exposure > or = 0.1 microTesla was 3.2 (6.7 adjusting for socioeconomic status), but this estimate was statistically very unstable, its 95% confidence interval being 0.4-23.4, and no indication of a dose-response relation emerged. Relative risk for acute lymphoblastic leukemia was 5.3 (95% confidence interval 0.7-43.5), while there was no increased risk for the other hematological malignancies.
CONCLUSIONS: Though the number of exposed children in this study was too low to allow firm conclusions, results were more suggestive of an excess risk of leukemia among exposed children than of a null relation."
"The strongest microwave effects were always observed in stem cells. This result may suggest both significant misbalance in DSB repair and severe stress response. Our findings that stem cells are most sensitive to microwave exposure and react to more frequencies than do differentiated cells may be important for cancer risk assessment and indicate that stem cells are the most relevant cellular model for validating safe mobile communication signals."
"Everyone is exposed to electromagnetic fields (EMFs) from electricity (extremely low frequency, ELF), communication frequencies, and wireless devices (radiofrequency, RF). Concern of health hazards from EMFs has increased as the use of cell phones and other wireless devices has grown in all segments of society, especially among children. While there has been strong evidence for an association between leukemia and residential or occupational exposure to ELF EMFs for many years, the standards in existence are not sufficiently stringent to protect from an increased risk of cancer. For RF EMFs, standards are set at levels designed to avoid tissue heating, in spite of convincing evidence of adverse biological effects at intensities too low to cause significant heating. Recent studies demonstrate elevations in rates of brain cancer and acoustic neuroma only on the side of the head where individuals used their cell phone. Individuals who begin exposure at younger ages are more vulnerable. These data indicate that the existing standards for radiofrequency exposure are not adequate. While there are many unanswered questions, the cost of doing nothing will result in an increasing number of people, many of them young, developing cancer."
"There was no clear association with cellular telephone phone use, but durations were relatively short (median 24-26 months), and there was a suggestion that risk may be increased for those with certain usage practices (ORs, 1.8-3.0 with lower confidence intervals >1.0) and those who used GSM service (OR, 2.1; 95% confidence interval, 1.1-4.0). Myeloid leukemia (acute and chronic combined) was associated with benzene (OR, 3.9; 95% confidence interval, 1.3-11), a nonspecific group of other solvents (2.3; 1.1-4.9), occupational pesticides that were mostly unspecified (3.8; 2.1-7.1), and working with or near powerlines (4.3; 1.3-15). No associations were found for diagnostic X-rays, cigarette smoking, or other occupational exposures."
"The list of cancers with increased risk in firefighters strongly overlaps the list of cancers at increased risk in workers exposed to electromagnetic fields (EMF) and radiofrequency radiation (RFR). Firefighters have increased exposure to RFR in the course of their work, from the mobile two-way radio communications devices which they routinely use while fighting fires, and at times from firehouse and fire vehicle radio transmitters. I suggest that some of the increased cancer risk in firefighters is caused by RFR exposure, and is therefore preventable. The precautionary principle should be applied to reduce the risk of cancer in firefighters, and workman's compensation rules will necessarily need to be modified."
"The strongest microwave effects were always observed in stem cells. This result may suggest both significant misbalance in DSB repair and severe stress response. Our findings that stem cells are most sensitive to microwave exposure and react to more frequencies than do differentiated cells may be important for cancer risk assessment and indicate that stem cells are the most relevant cellular model for validating safe mobile communication signals."
"Thirty years ago, Nancy Wertheimer and Ed Leeper published the first report on the association between childhood cancer and "electrical current configuration" of houses in Denver, Colorado. In 2001 the International Agency for Research on Cancer defined 50-60 Hz magnetic fields as "possibly carcinogenic to humans" because of the "limited evidence" of carcinogenicity of residential exposure relatively to childhood leukemia. With respect to health effects other than cancer, namely neurodegenerative disorders, miscarriage, subtle differences in the timing of melatonin release, altered autonomic control of the heart, and changes in the number of natural killer cells, some open questions still remain. Several authors recommended further investigation of the possible long-term effects of magnetic fields, focussing on populations experiencing high exposure levels. In this frame a research team of ISS searched for a suitable location to implement an epidemiological study aimed at a wide range of outcomes for which a priori hypotheses could be formulated. The recently published findings of this project showed an increase of primary and secondary malignant neoplasms, ischaemic disease and haematological diseases. Future studies should thus address the most exposed sectors of the population, take into account different outcomes (all neoplasms, neurodegenerative diseases, immunological disorders, specific cardiovascular effects) and follow research protocols that enable subsequent pooled analyses. A precautionary approach may provide the frame for decision making where the available resources for environmental remediation be prioritatively allocated to worst-off situations."
"Our results suggest a possible association between electric transformers and power lines and the XRCC1 Ex9+16A allele in patients with childhood AL."
"The postulated presence of magnetic nanoparticles located in hematopoietic stem cells could constitute a cancer risk factor. Superparamagnetic nanoparticles can possibly mediate increased level of leukaemia caused by background exposure to low-frequency weak EMF."
"ELF MFs have been reported to enhance the effects of known carcinogenic or mutagenic agents in a few animal studies and in several in vitro studies. This paper discusses the findings of studies on such combined effects. The majority of in vitro studies have reported positive findings, which supports the conclusion that MFs of 100 microT or higher interact with other chemical and physical agents. Further studies should address biophysical mechanisms and dose-response relationship below 100 microT."
"Overall, for new studies, both brain cancer and leukemia showed small increases in risk estimates, 10% and 13%, respectively. Notably, pooled risk estimates were lower than in past meta-analyses, and leukemia subtypes showed no consistent pattern when past and present meta-analyses were compared."
"With the exception of high cut-point analyses (0.3/0.4 microT), where the possibility of a moderate risk increase cannot be excluded, no increase in childhood brain cancer risk was evident for any of the exposure metrics."
"A review of electric field studies provides evidence that (i) diurnal variation in the natural atmospheric electric field may itself act as a weak Zeitgeber; (ii) melatonin disruption by electric fields occurs in rats; (iii) in humans, disturbances in circadian rhythms have been observed with artificial fields as low at 2.5 V/m. Specific suggestions are made to test the aspects of the hypothesis."
"A precautionary limit should be adopted for outdoor, cumulative RF exposure and for cumulative indoor RF fields with considerably lower limits than existing guidelines, see the BioInitiative Report. The current guidelines for the US and European microwave exposure from mobile phones, for the brain are 1.6W/Kg and 2W/Kg, respectively. Since use of mobile phones is associated with an increased risk for brain tumour after 10 years, a new biologically based guideline is warranted. Other health impacts associated with exposure to electromagnetic fields not summarized here may be found in the BioInitiative Report at www.bioinitiative.org."
"Although recognizing that this study has limitations, the results raise the possibility that prolonged residence close to high-voltage power lines, especially early in life, may increase the risk of the development of MPD and LPD later."
"This large case-control study identified a significantly increased risk of leukemia among the offspring of men likely to have been occupationally exposed to EMF, with differing associations between males and females. Increased risks of chondrosarcoma and renal carcinoma were also seen, although based on smaller numbers. Further detailed investigations in this area are required to understand this association."
"The odds ratio for all types of leukemia was 2.15 (95% confidence interval (CI): 1.00, 4.67) among children who resided within 2 km of the nearest AM radio transmitter as compared with those resided more than 20 km from it. For total RFR exposure from all transmitters, odds ratios for lymphocytic leukemia were 1.39 (95% CI: 1.04, 1.86) and 1.59 (95% CI: 1.19, 2.11) for children in the second and third quartiles, respectively, versus the lowest quartile. Brain cancer and infantile cancer were not associated with AM RFR."
"The results of this stakeholder investigation found convincing evidence that there was a small increase in risk of childhood leukaemia for those living in powerfrequency magnetic fields above 0.4 microTesla. It left open unresolved correlations between powerfrequency EMFs and other conditions, such as miscarriage, depression, breast cancer, adult leukaemia, ALS and brain cancer."
"High-voltage (HV) sources, including the HV overhead power lines that are the focus of public concern, accounted for 23% of the exposures above 0.2 microT, and 43% of those above 0.4 microT. Public health interest has focused on the consideration of precautionary measures that would reduce exposure to power frequency magnetic fields. Our study provides a basis for considering the options for exposure mitigation in the UK. For instance, in elevated-exposure homes where net currents are higher than usual, if it is possible to reduce the net currents, then the exposure could be reduced for a sizeable proportion of these homes."
"More children in developing countries like Iran live close to very high voltage lines, and they experience relatively more harmful effects from the Magnetic Fields, in comparison with children in developed countries. Residence near very high voltage overhead power lines, in distances < or = 500 meters, and Magnetic Fields >0.45 microT, should be considered a risk factor for the pathogenesis of acute leukaemias in children."
"In this review, a general overview is given about oxidative stress, as well as experimental studies are reviewed as they are related to changes in oxidant and antioxidant content after ELF-EMF exposure inducing different biological effects. Finally, we conclude from our review that modulations on the oxidant and antioxidant level through ELF-EMF exposure can play a causal role in cancer development."
"An iteration equation is suggested that uses only a few model parameters and describes basic regularities observed in cancer onset. In the model context, relatively small chronic variations in the intracellular content of free radicals may markedly affect the probability of a cell to become a cancer cell. On the other hand, magnetic nanoparticles are shown to be an endogenous source of chronic magnetic exposure that increases the local concentration of free radicals. An enhanced level of leukaemia in early childhood is assumed to originate from magnetic nanoparticles located in hematopoietic stem cells."
"We first examine separately the evidence on trends in exposure to EMFs and on trends in leukemia rates, and then compare the two. Both incidence rates and exposures have increased, but there are so many approximations and assumptions involved in connecting the two trends that we cannot regard the ecologic evidence as providing any meaningful evidence for or against a causal link."
"The fraction of childhood leukemia cases possibly attributable to ELF exposure across the globe appears to be small. There remain, however, a number of uncertainties in these AF estimates, particularly in the exposure distributions."
"A new study, Draper et al., looks at residence close to high-voltage power lines, one source of exposure to such fields, and its design avoids any obvious bias. It finds elevated childhood leukemia rates, but extending too far from the power lines to be straightforwardly compatible with the existing literature. This leads to an examination of alternative explanations: magnetic fields, other physical factors, such as corona ions, the characteristics of the areas power lines pass through, bias, and chance. The conclusion is that there is currently no single preferred explanation, but that this is a serious body of science that needs further work until an explanation is found."
"Most of the leukemia cases in the highest exposure category had MF levels far above 0.4 microT. Our results provided additional evidence that high MF exposure was associated with a higher risk of childhood leukemia, particularly of ALL."
"These recent studies, using the exposure methods and the cut-off levels set a priori, each concluded that there was little evidence of any association. The pooled analyses, using different exposure measures and different cut-offs, conclude that an association exists at high exposure levels. It is not clear if the results of the pooled analysis are more valid than those of the recent major studies, although this has been often assumed in influential reviews."
"Most of the studies reviewed used magnetic fields of 100 microT or higher, so the findings are not directly relevant for explaining the epidemiological findings suggesting increased risk of childhood leukemia above 0.4 microT. However, confirmed adverse effects even at 100 microT would have implications for risk assessment and management, including the need to reconsider the exposure limits for magnetic fields. There is an obvious need for further studies on combined effects with magnetic fields."
"The results indicate an association between T-cell NHL and the use of cellular and cordless telephones, however based on low numbers and must be interpreted with caution. Regarding B-cell NHL no association was found."
"Magnetic field strengths were low, with average (RMS) values of 0.03 +/- 0.02 microT across all residences. In contrast, background field ellipticities were high, on average 47 +/- 11%. Microwave and electric ovens produced the highest ellipticities: mean respective values of 21 +/- 21% and 21 +/- 17% were observed 20 cm away from these appliances. There was a negative correlation between field strength and field polarization, which we attribute to the higher relative field contribution close to each individual (single-phase) appliance. The measurements demonstrate that domestic magnetic fields are extremely complex and cannot simply be characterized by traditional measurements such as time-weighted average or peak exposure levels. We conclude that ellipticity should become a relevant metric for future epidemiological studies of health and ELF-MF exposure."
"Such melatonin disruption has been shown in animals, especially with exposure to electric and/or rapid on/off magnetic fields. Equivocal evidence has been obtained from controlled laboratory magnetic field exposures of volunteers, although the exposure conditions are generally atypical of neighborhood exposures. In contrast, support for the hypothesis is found in the body of studies showing magnetic field disruption of melatonin in human populations chronically exposed to both electric and magnetic fields associated with electricity distribution. Further support comes from the observation that melatonin is highly protective of oxidative damage to the human haemopoietic system. Aspects of the hypothesis are amenable to further investigation."
"A maximum electric field enhancement of 50% is observed. Another model of bone marrow stroma cells is implemented only in FEM using thin film approximation. The transmembrane potential (TMP) change across the gap junctions is found to range from several to over 200 microV. The two results suggest that imperceptible contact currents can produce biologically significant TMP change at least in a limited number of bone marrow stroma cells."
"There is an association between childhood leukaemia and proximity of home address at birth to high voltage power lines, and the apparent risk extends to a greater distance than would have been expected from previous studies. About 4% of children in England and Wales live within 600 m of high voltage lines at birth. If the association is causal, about 1% of childhood leukaemia in England and Wales would be attributable to these lines, though this estimate has considerable statistical uncertainty."
"This review focuses on research examining the effects of EMFs on birds; most studies indicate that EMF exposure of birds generally changes, but not always consistently in effect or in direction, their behavior, reproductive success, growth and development, physiology and endocrinology, and oxidative stress under EMF conditions."
"The Residential Sources Study was set up to investigate the sources of power frequency magnetic fields that contributed to average residential exposure estimates of 0.2 μT and above in the UK Childhood Cancer Study (UKCCS). The work was carried out by the National Radiological Protection Board (NRPB), now the Radiation Protection Division (RPD) of the Health Protection Agency (HPA), on behalf of the Leukaemia Research Fund Epidemiology and Genetics Unit at the University of York (EGU), as part of an extension of the UKCCS EMF Hypothesis - that exposure to extremely low frequency electromagnetic fields (specifically power frequency magnetic fields) may play a role in the aetiology of childhood cancer."
"Long-term exposure to extremely-low-frequency electromagnetic fields (ELF EMFs) greater than 0.4 microT has been linked, by epidemiological studies, to a small elevated risk of childhood leukaemia. Laboratory-based experiments have been claimed to show that ELF EMFs induce a variety of biological responses, although these claims are controversial. Recent experiments by Ivancsits et al. [Mutat. Res. 519 (2002) 1; Int. Arch. Occup. Environ. Health 76 (2003) 431; Mech. Age. Dev. 124 (2003) 847; H.W. Rüdiger, S. Ivancsits, E. Diem, O. Jahn, Genotoxic effects of ELF-EMF on human cells in vitro, Bioelectromagnetics Society 25th Annual Meeting, Maui, USA, 2003] suggest that ELF EMFs are genotoxic, on the basis of observations that intermittent exposures induce single-strand breaks (SSB) and double-strand DNA breaks (DSB) in the DNA of cultured human fibroblasts. The implications of these findings are discussed."
"Taken together, these EMF induced reactions could lead to a higher incidence of DNA damage and therefore, to an increased risk of tumour development. While the effects on melatonin and the extension of the lifetime of radicals can explain the link between EMF exposure and the incidence of for example leukaemia, the two additional mechanisms described here specifically for mouse macrophages, can explain the possible correlation between immune cell system stimulation and EMF exposure."
"However, the evidence for a carcinogenic effect of other forms of nonionizing radiation, such as those associated with mobile telephones or electricity transmission lines, is not convincing, although the possibility of a link between childhood leukaemia and extremely low-frequency electromagnetic fields cannot be dismissed entirely."
"We observed higher mortality rates for all cancers and leukemia in some age groups in the area near the AM radio broadcasting towers. Although these findings do not prove a causal link between cancer and RF exposure from AM radio broadcasting towers, it does suggest that further analytical studies on this topic are needed in Korea."
"Among the 11 high-power sites, there were significantly increased incidences of leukemia in 2 areas and of brain cancer in 1 area. Future studies should incorporate additional detailed exposure assessments and a strong analytical study design to explore the possible association between radiofrequency radiation from AM radio transmitters and cancer."
"When residential magnetic fields are evaluated, the two upper residential time weighted average magnetic field categories showed non-significant elevated odds ratios (ORs) for all leukemia combined (OR: 1.3, 95% confidence interval (CI) 0.7-2.5 and OR: 1.5, 95% CI: 0.8-3.0). The increased risk was confined to chronic lymphocytic leukemia, acute lymphocytic and acute myeloid leukemia. Lymphoma showed a non-significant lower OR in the upper exposure category. Multiple myeloma showed non-significant elevated ORs. Occupational exposure showed no significant association to exposure for any site. CONCLUSIONS: Some elevated ORs were observed in the present study, but the results are based on small numbers and no firm conclusions can be drawn."
"There was a significant difference in survival rates between the 2 groups (log-rank test, p = 0.03; Wilcoxon, p = 0.05). The 5-yr survival in the inner ring of municipalities was 55%, and in the outer ring was 71% (i.e., subjects in the inner ring were 23% less likely to survive than those in the outer ring); at 10 yr, survival in the inner and outer rings was 33% and 62%, respectively. Following adjustment, the mortality rate ratio that the authors used to compare the inner ring with the outer ring was 2.1 (95% confidence interval = 1.1, 4.0). There was an association between residential proximity to the television towers and decreased survival among cases of childhood leukemia in North Sydney, Australia."
"Our results are compatible with an increased risk of childhood leukemia among children whose mothers were exposed to the highest occupational levels of ELF-MF during pregnancy."
"This correlation, combined with both frequent exposure opportunity for bathing children and substantial dose to bone marrow resulting from contact, lead us to suggest that contact current due to V(W-E) could explain the association between high residential magnetic fields and childhood leukemia."
"For selected illnesses, this paper estimates the annual number of excess cases that might occur near high-voltage powerlines in the UK. Within 150m of powerlines, magnetic field exposures above 0.1 microT are postulated to result in 9000 excess cases of depression in adults and 60 cases of suicide. Electric field effects can mediate increased exposure to air pollution. Within 400m of powerlines, this may result annually in 200-400 excess cases of lung cancer, 2000-3000 cases of other illnesses associated with air population and 2-6 cases of childhood leukaemia. Seventeen cases of non-melanoma skin cancer might occur by exposure directly under powerlines."
"Although the study adds evidence of an excess of leukemia in a population living near high-power radio transmitters, no causal implication can be drawn. There is still insufficient scientific knowledge, and new epidemiologic studies are needed to clarify a possible leukemogenic effect of residential exposure to radio frequency radiation."
"The Risk Evaluation analyzes the potential human health risks of magnetic field exposure. Specifically, this document provides an evaluation of the animal, laboratory and human evidence that shows how exposure to 50/60 Hz magnetic fields may or may not increase human health risks. The Risk Evaluation is based on the results of published research studies, with emphasis on new studies, the National Institute of Environmental Health Sciences (NIEHS) Working Group Report, and the results of the California EMF Program Studies."
"Among all the outcomes evaluated in epidemiologic studies of EMF, childhood leukemia in relation to postnatal exposures above 0.4 microT is the one for which there is most evidence of an association. The relative risk has been estimated at 2.0 (95% confidence limit: 1.27-3.13) in a large pooled analysis. This is unlikely to be due to chance but, may be, in part, due to bias."
"The risk of childhood leukaemia was higher than expected within 6 km from the station (Standardized Incidence Ratio = 217; 95% Confidence Interval 99-405). Stone's test showed a significant decrease in risk with increasing distance both for male adult mortality (p-value = 0.03) and for childhood incidence (p-value = 0.04). A Score test, showed a significant decrease in risk of childhood incidence as function of the distance. The main limitations of this study are the small number of observed cases and the use of distance as a proxy for RF exposure. Further research will require a systematic campaign of electromagnetic field measurements to allow better assessment of the population exposure."
"Finally, the results of the analyses using dichotomous and continuous exposure model are combined with national exposure data to estimate the population attributable risk of childhood leukemia among children in the US. If an association exists, as many as 175-240 cases of childhood leukemia in the US may be due to magnetic field exposure."
"A significant association was seen between childhood leukaemia and magnetic field exposure during the night (OR = 3.21, 95% CI 1.33-7.80). A dose-response-relationship was observed after combining the data of all German studies on magnetic fields and childhood leukaemia. The evidence for an association between childhood leukaemia and magnetic field exposure in our study comes from a measure of exposure during the night."
"During 1949-1951, all states showed a peak in leukemia mortality at ages 2-4. At ages 0-1, leukemia mortality was not related to electrification levels. At ages 2-4, there was a 24% (95% confidence interval (CI), 8%-41%) increase in leukemia mortality for a 10% increase in percent of homes served by electricity. The childhood leukemia peak of common acute lymphoblastic leukemia may be attributable to electrification."
"Our results contradict the idea that the magnetic field association with leukemia is less consistent than the wire code association with leukemia, although analysis of the four studies with both measures indicates that the wire code association is not explained by measured fields. The results also suggest that appreciable magnetic field effects, if any, may be concentrated among relatively high and uncommon exposures, and that studies of highly exposed populations would be needed to clarify the relation of magnetic fields to childhood leukemia."
"In summary, the 99.2% of children residing in homes with exposure levels < 0.4 microT had estimates compatible with no increased risk, while the 0.8% of children with exposures >/= 0.4 microT had a relative risk estimate of approximately 2, which is unlikely to be due to random variability."
"Univariate adjustment for individual variables changed the odds ratio for ALL by less than 8%, while simultaneous adjustment for several factors reduced the estimate by a maximum of 15%. We conclude that while confounding alone is unlikely to be an important source of bias in our own and previous studies of magnetic fields, selection bias may be more of a concern, particularly in light of the generally low response rates among controls in case-control studies."
"These risks increased in magnitude when analysis was restricted to children under 6 years of age at diagnosis or to those with acute lymphoblastic leukemia. For children younger than 6 years at diagnosis, outside perimeter measurements of the residence, > or = 0.15 microT, were associated with increased leukemia risk (OR = 3.45, 95% CI = 1.14-10.45)."
"A comparison between the resulting averages showed that the total spectral power of the cytosolic Ca2+ oscillator was reduced by exposure of the cells to an alternating magnetic field and that the effect increased in an explicit dose-response manner. The same relationship was observed within the 0-10 mHz (10 x 10(-3) Hz) subinterval of the Ca2+ oscillation spectrum. For subintervals at higher frequencies, the change caused by the exposure to the magnetic field was not significant."
"From 1992 to 1996, we obtained electromagnetic field measurements in two population-based case-control studies on childhood leukemia in the northwestern part of Germany and in Berlin. Exposure assessment comprised residential 24-hour measurements and short-term measurements. We obtained 24-hour measurements for a total of 176 cases and 414 controls. We compared subjects exposed to median 24-hour measurements of 0.2 microT or more with those exposed to lower amounts. Multivariate regression analysis revealed an odds ratio of 2.3 (95% confidence interval = 0.8-6.7)."
"This study raises interest in a possible association between exposure to RF radiation and cancer risk. However, the study power was very small, and the possible confounding effects of exposure to solvents and vinyl chloride monomer (VCM) could not be ruled out. The hypothesis of an increased risk of cancer after radiofrequency exposure should be further explored by means of analytical studies characterised by adequate power and more accurate exposure assessment."
"This meta-analysis tends to confirm the presence of an association between exposure to magnetic fields and leukaemia among people who reside in the vicinity of high voltage transmission electric lines of > or = 49 kV. There is consistency across studies. Measures of exposure used in the studies were either distance from the lines or calculated fields estimated from pertinent line features. The results apply to adults as well as to children."
"For children exposed to more than 0.2 microT, an elevated but not significant odds ratio (OR) was observed (OR = 3.2, 95 percent confidence interval = 0.7-14.9). These figures are based on only four leukemia cases and three controls since only 1.5 percent of the study population was classified as highly exposed. Exploratory analyses revealed ORs that were not statistically significantly increased for other characteristics of the magnetic field at varying cut-points. The results are comparable with those from other studies. Although not statistically significant, they may indicate a positive association between EMF and childhood leukemia."
"The risk of adult leukemia within 2 km was 1.83 (95% confidence interval 1.22-2.74), and there was a significant decline in risk with distance from the transmitter (p = 0.001). These findings appeared to be consistent over the periods 1974-1980, 1981-1986, and were probably largely independent of the initially reported cluster, which appeared to concern mainly a later period."
"The results were based on the separate analysis of 870 cases of leukemia, 577 brain tumors, and 1,980 female breast cancers. We estimated the risk of leukemia among those exposed to magnetic fields of > 0.2 microtesla (microT), relative to the risk among those exposed to fields of < 0.1 microT; the odds ratio was 1.4 [95% confidence interval (CI) = 1.0-1.9]. For distance < 50 meters relative to > or = 100 meters, the relative risk was 2.0 (95% CI = 1.4-2.9). For brain tumors and female breast cancers, the odds ratios were close to unity."
"For all ages, the rate ratio for total leukaemia incidence was 1.24 (95% confidence interval [CI], 1.09-1.40). Among children, the rate ratio for leukaemia incidence was 1.58 (95% CI, 1.07-2.34) and for mortality it was 2.32 (95% CI, 1.35-4.01). The rate ratio for childhood lymphatic leukaemia (the most common type) was 1.55 (95% CI, 1.00-2.41) for incidence and 2.74 (95% CI, 1.42-5.27) for mortality. Brain cancer incidence and mortality were not increased. We found an association between increased childhood leukaemia incidence and mortality and proximity to TV towers."
"The cancer morbidity rate for RF/MW-exposed personnel for all age groups (20-59 years) reached 119.1 per 100,000 annually (57.6 in non-exposed) with an OER of 2.07, significant at P < 0.05. The difference between observed and expected values results from higher morbidity rates due to neoplasms of the alimentary tract (OER = 3.19-3.24), brain tumours (OER = 1.91) and malignancies of the haemopoietic system and lymphatic organs (OER = 6.31). Among malignancies of the haemopoietic/lymphatic systems, the largest differences in morbidity rates between exposed and non-exposed personnel were found for chronic myelocytic leukaemia (OER = 13.9), acute myeloblastic leukaemia (OER = 8.62) and non-Hodgkin lymphomas (OER = 5.82)."
"The associations of cancer with conductive plumbing and with this exposure metric both suggest that cancer risk is increased among persons with elevated magnetic field exposure from residential ground currents."
"For calculated magnetic field levels of 0.2 microT or more closest in time to diagnosis, we found an elevated relative risk (RR) for acute myeloid leukemia [RR = 1.7; 95% confidence interval (CI) = 0.8-3.5] and chronic myeloid leukemia [RR = 1.7; 95% CI = 0.7-3.8]. Using cumulative exposure for the 15 years preceding diagnosis, we found relative risk estimates for acute and chronic myeloid leukemia of 2.3 (95% CI = 1.0-4.6) and 2.1 (95% CI = 0.9-4.7), respectively, for the highest exposure category. For chronic lymphatic leukemia and for central nervous system tumors, relative risk estimates were close to or below unity."
"The odds ratio (OR) for having lived within 2.6 miles of the radio towers before diagnosis was 2.0 (95% CI 0.06 to 8.3). The clustering may have been a chance event, but because of its peculiar characteristics, we feel it should be noted."
"A significant association was seen between all major types of childhood cancer combined and exposure to magnetic fields from high voltage installations of > or = 0.4 microT (odds ratio 5.6)."
"No statistically significant increases in all cancers and in leukaemia and lymphoma were found in children at any exposure level. A statistically significant excess of nervous system tumours was found in boys (but not in girls) who were exposed to magnetic fields of > or = 0.20 microT or cumulative exposure of > or = 0.40 microT years."
"When historical calculations were used as exposure assessment for childhood leukemia with cutoff points at 0.1 and 0.2 microtesla (microT), the estimated relative risk increased over the two exposure levels and was estimated at 2.7 (95% confidence interval (CI) 1.0-6.3) for 0.2 microT and over; p for trend = 0.02. When the upper cutoff point was shifted to 0.3 microT, the relative risk was 3.8 (95% CI 1.4-9.3); p for trend = 0.005. These results persisted when adjustment for potential confounding factors was made."
"Exposure conditions vary greatly among different end points measured, making comparisons and conclusions among experiments difficult. Although most of the available evidence does not suggest that electric and/or magnetic fields cause DNA damage, the existence of some positive findings and limitations in the set of studies carried out suggest a need for additional work."
"An association between the Denver Wertheimer-Leeper wiring configuration and childhood leukemia risk was observed (odds ratio for very high relative to very low current and underground configuration combined = 2.15, 95% confidence interval 1.08-4.28; p for trend = 0.008) and was not substantially altered by adjustment for potential confounding factors."
"Only 0.6% of subjects lived within 100 m of an overhead power-line, and the risk of leukaemia relative to cancer controls for residence within 100 m was 1.45 (95% confidence interval (CI) 0.54-3.88); within 50 m the relative risk was 2.0 but with a wider confidence interval (95% CI 0.4-9.0). Over 40% of subjects lived within 100 m of a substation, for which the relative risk of leukaemia was 0.99. Residence within 25 m carried a risk of 1.3 (95% CI 0.8-2.0). Weighted exposure indices incorporating measures of the current load carried by the substations did not materially alter these risks estimates. For persons aged less than 18 the relative risk of leukaemia from residence within 50 m of a substation was higher than in adults (PR = 1.5, 95% CI 0.7-3.4)."
"Measured magnetic fields under low power use conditions had a modest association with cancer incidence; a cutoff score of 2.0 milligauss resulted in an odds ratio of 1.4 (95% confidence interval (CI) = 0.6-2.9) for total cancers and somewhat larger odds ratios (ORs) for leukemias (OR = 1.9), lymphomas (OR = 2.2), and soft tissue sarcomas (OR = 3.3). Neither magnetic fields (OR = 1.0) nor electric fields (OR = 0.9) under high power use conditions were related to total cancers. Wire codes associated with higher magnetic fields were more common among case than control homes. The odds ratio to contrast very high and high to very low, low, and buried wire codes was 1.5 (95% CI = 1.0-2.3) for total cases, with consistency across cancer subgroups except for brain cancer (OR = 2.0) and lymphomas (OR = 0.8). Contrasts of very high to buried wire code homes produced larger, less precise odds ratios of 2.3 for total cases, 2.9 for leukemias, and 3.3 for lymphomas."
"Visible 200-kv wires were noted at 45 of 2,098 dwellings and were found twice as frequently among cases as among controls (P less than .05). The magnetic field measured at the dwelling varied between 0.0004 to 1.9 microT (mean value 0.069 microT). The magnetic field was higher (0.22 microT) at dwellings with visible 200-kV wires than at those without such wires. Magnetic fields of 0.3 microT or more were measured at 48 dwellings, and were found twice as frequently among cases as among controls (P less than .05). The difference was most pronounced for dwellings of nervous system tumors and was less for leukemias."
"The effects of nonionizing electromagnetic (EM) field interactions with the human body were reported and human related studies were collected. Nonionizing EM fields are linked to cancer in humans in three different ways: cause, means of detection, and effective treatment. Bad and benign effects are expected from nonionizing EM fields and much more knowledge is necessary to properly categorize and qualify EM field characteristics. It is concluded that knowledge of the boundary between categories, largely dependent on field intensity, is vital to proper future use of EM radiation for any purpose and the protection of the individual from hazard."